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Serum estradiol concentration, estradiol-to-progesterone ratio and sputum IL-5 and IL-8 concentrations are increased in luteal phase of the menstrual cycle in perimen-strual asthma patients


A. Semik-Orzech1 asemik@interia.pl, S. Skoczyński1,2, W. Pierzchała1

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Doi
https://doi.org/10.23822/EurAnnACI.1764-1489.09

Summary
Background
. The results of the research on perimenstrual asthma (PMA) pathophysiology are inconsistent and the role of sex hormones remains inconclusive. The aim of the study was to evaluate the influence of serum sex steroid (and other) hormones' concentrations on lower air-way inflammation of PMA patients. Methods. Thirty-three women of childbearing age diag-nosed as: PMA (n = 13), non-PMA asthmatics (n = 10), and healthy controls (n = 10) were pro-spectively followed for 12 weeks over 2 consecutive menstrual cycles. On the 10th and 26th day of each cycle serum 17â-estradiol, progesterone, testosterone, androstenedione, dehydroepi-androsterone, cortisol, thyroid stimulating hormone and prolactin were measured, and sputum was induced. Sputum inflammatory cell count and IL-5, -6, -8, -10 concentrations were deter-mined. Results. When compared to non-PMA asthmatics, the luteal phase of the cycle in PMA subjects was associated with increased serum estradiol concentration, estradiol-to-progesterone ratio (p < 0.001, p = 0.001, respectively) and sputum IL-5 and IL-8 concentrations (p = 0.045, p = 0.039; respectively). Decreased serum testosterone levels (p < 0.05) and a trend to increased se-rum prolactin levels in both phases of the menstrual cycle in PMA subjects were observed. Spu-tum analysis in PMA patients revealed increased total inflammatory cell count in both phases of the menstrual cycle (p < 0.05), when compared to non-PMA asthmatics. Conclusions. The luteal phase of the cycle in PMA patients is associated with increased serum estradiol levels with con-current higher sputum concentration of IL-5 and IL-8. Serum testosterone levels are decreased, and total number of sputum inflammatory cells is increased in PMA patients in both phases of the menstrual cycle.


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Semik-Orzech et al. Increased serum estradiol and sputum IL-5 and IL-8 levels in luteal phase of the menstrual cycle in PMA patients. Eur Ann Allergy Clin Immunol. 2017;49(4):161-170. doi:10.23822/EurAnnACI.1764-1489.09