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Table of Contents »

Immediate-type hypersensitivity reaction to Mannitol as drug excipient (E421): a case report

G.F. Calogiuri, L. Muratore, E. Nettis, A.M. Casto, E. Di Leo, A. Vacca

Allergic reactions to mannitol have been reported rarely, despite its widespread use as a drug and as a food excipient. This is the first case report in which oral mannitol induces an immediate type hypersensitivity as a drug excipient, in a 42 year old man affected by rhinitis to olive tree pollen. Unusual and undervalued risk factors for mannitol hypersensitivity are examined.

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