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Severe bronchiectasis in a patient with common variable immunodeficiency

L. Paulos Viegas, S.P. Silva, S.L. Silva, A. Campos Melo, A. Serra-Caetano, M. Branco-Ferreira, P. Azevedo, M.C. Pereira-Santos, M. Pereira-Barbosa

Background. Bronchiectasis are common in Common Variable Immunodeficiency. These patients are prone to infection, leading to progressive lung destruction and accelerated FEV1 decline. Clinical case. 40 year-old man, with recurrent respiratory infections, autoimmunity and diarrhea since age 7. At 17 CVID was diagnosed and IVIgG was started. During the following years, respiratory symptoms progressively worsened and bronchiectasis was found on thoracic computed tomography. Bronchoscopy revealed Pseudomonas aeruginosa in bronchoalveolar lavage and bronchial secretions cultures. Eradication therapy led to clinical improvement. Discussion. This case report stresses the importance of regular microbiological screening and appropriate antibiotherapy. Early/aggressive treatment may significantly impact on patients' evolution.

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