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Table of Contents »

Omalizumab treatment in patient with severe Asthma and Eosinophilic Granulomatosis with Polyangiitis. A case report

A. Graziani, O. Quercia, F. Girelli, A. Martelli, F. Mirici Cappa, G.F. Stefanini

Eosinophilic Granulomatosis with Polyangiitis (EGPA), formerly named Churg Strauss Syndrome, is a multisystem disorder characterized by chronic rhinosinusitis, asthma, and prominent peripheral blood eosinophilia; it is classified as a vasculitis of the small and medium sized arteries, although the vasculitis is often not clinically apparent in the initial phases of the disease. We present the case of a woman with EGPA who was frequently treated with high dose steroid therapy during hospital admission for refractory asthma. After December 2008, the date when we started Omalizumab, we observed a significative reduction of circulating eosinophils and IgE serum level, and the patient was no more ospitalized for respiratory failure or asthma attacks.

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