Background and Objective: Some studies hypothesize the existence of cross-reactivity between allergy to Cupressus sempervirens pollen and plant-derived foods.We aimed to assess whether this holds true.Methods: 72 patients monosensitized to cypress pollen were investigated for food allergy to peach, apple, tomato and Juniperius oxycedrus berry. Results: No patient had a history of clinical allergy or showed in-vitro or in-vitro reactivity to peach, apple, and tomato. Two patients scored positive on SPT with Juniperius oxycedrus berry but in-vitro tests ruled out cross-reactivity with the corresponding pollen. Conclusion: Airborne allergy to Cupressaceae pollen is not associated with allergy to plant-derived foods.