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Table of Contents »

Immunoglobulin G in IgE-mediated allergy and allergen-specific immunotherapy

S. Hofmaier, P. Comberiati, P.M. Matricardi

Allergen-specific IgG antibodies play a significant role in allergen-specific tolerance, either naturally induced or generated by specific immunotherapy. Nevertheless, the underlying mechanisms are still debated, and allergen-specific IgG determinations are not recommended as a diagnostic tool in IgE-mediated allergy. This review summarizes the latest findings on the immunological and diagnostic role of IgG antibodies in respiratory and food allergies, and during allergen-specific immunotherapy.

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