Kounis syndrome: an underestimated emergencyGiuliana Zisa email@example.com 1, Antonio Panero2, Azzurra Re3, Marco Giovanni Mennuni4, Giuseppe Patti4,5, Mario Pirisi5,6Show more: Authors information and Publication history
Allergy Unit, Department of Internal Medicine, Hospital Maggiore della Carità, Novara, Italy2
Department of Medicine, Hospital of Biella, Biella, Italy3
Department of Medicine, Hospital Maggiore della Carità, Novara, Italy4
Division of Cardiology, Hospital Maggiore della Carità, Novara, Italy5
Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy6
Division of Internal Medicine, Hospital Maggiore della Carità, Novara, Italy
Published: 18 July 2022
Accepted: 11 July 2022
Received: 13 March 2022
Kounis syndrome (KS) is defined as a rare cause of an acute coronary syndrome associated with systemic allergic reactions. To establish the prevalence of KS among the patients with diagnosis of anaphylaxis, we described clinical features, cardiological and allergological outcomes of patients evaluated in our Allergy Outpatient Clinic. Methods.
A retrospective study was carried out in the Allergy Unit of Novara hospital, from January 2008 to March 2020. Skin tests and in vitro tests were performed with suspected etiological agents. Results.
We found 9 adults with KS (2%) out of 444 subjects who had experienced anaphylactic reactions (4/9 to hymenoptera stings, 5/9 to drugs). Conclusions.
The present study highlights the importance of suspicion of KS that appears not so uncommon in patients with anaphylaxis. KS seems to be a rare disease because unrecognized in diagnosis of anaphylaxis.
Anaphylaxis; coronary vasospasm; hypersensitivity; drugs; Hymenoptera.
Cite this article as:
Zisa G, Panero A, Re A, Mennuni MG, Patti G, Pirisi M. Kounis Syndrome: an underestimated emergency. Eur Ann Allergy Clin Immunol. 2023;55(6):294-302. doi: 10.23822/EurAnnACI.1764-1489.260.