Kikuchi-Fujimoto Disease and COVID-19 vaccination: pharmacovigilance approachAdrian Rodríguez-Ferreras firstname.lastname@example.org, Iván Maray2, Covadonga Coya-Fernández1, Manuela María Octavio-Bocigas1, Manuel Felicísimo Fernández-del Río1, Susana Casares-López1, Jesús Ruiz-Salazar1Show more: Authors information and Publication history
Pharmacovigilance Division, Department of Pharmacy, Directorate General of Health Policy and Planning,
Regional Ministry of Health of the Principality of Asturias, Oviedo, Spain2
Department of Pharmacy, Hospital Universitario Central de Asturias, Oviedo, Spain
Published: 15 November 2022
Accepted: 14 November 2022
Received: 19 September 2022
Kikuchi-Fujimoto Disease (KFD) or histiocytic necrotizing lymphadenitys is a rare disorder characterized by subacute necrotizing regional lymphadenopathy. It is usually presented as painful cervical nodes and associated with fever, headache, night sweats, nausea, vomiting and sore throat. Etiology of KFD is still unclear, two theories have been proposed: infections and autoimmune origin. Due to recent reports of KFD related to COVID-19 vaccination, the novelty of the mechanism of these vaccines and the immunomodulated role of both matters, a literature and adverse event databases review was carried out in order to shed light on the relationship between these two matters. Methods.
A search in the Spanish and the European adverse events databases (FEDRA and Eudravigilance) was performed. Search criteria were any drug and the diagnosis "Histiocytic necrotising lymphadenitis" according to the Medical Dictionary for Medical Activities version 25.0. All adverse events registered as June 2, 2022, were included. Results.
FEDRA encompassed two KFD reports, one related to a mRNA COVID-19 vaccine. Eudravigilance included a total of 62 KFD cases, 14 of them associated to COVID-19 vaccines and eight to other vaccines. Conclusions.
Pharmacovigilance is of utter importance in detecting adverse events caused by new vaccines. More research is needed to establish a final connection between KFD and COVD-19 vaccines, but due to the physiopathology of the condition, how vaccines stimulate the immune system and the high number of reported KFD cases with vaccines given its rare incidence, it is plausible to think that both entities are related.
Kikuchi-Fujimoto; vaccines; lymphadenopathy.
Cite this article as:
Rodríguez-Ferreras A, Maray I, Coya-Fernández C, Octavio-Bocigas MM, Fernández-Del Río MF, Casares-López S, Ruiz-Salazar J. Kikuchi-Fujimoto Disease and COVID-19 vaccination: pharmacovigilance approach. Eur Ann Allergy Clin Immunol. 2023;55(6):278-282. doi: 10.23822/EurAnnACI.1764-1489.273.