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European Annals of Allergy and Clinical Immunology ISSN 1764-1489

2023

Table of Contents »

35 years of autologous serum skin test in chronic spontaneous urticaria: what we know and what we do not know


R. Asero r.asero@libero.it1, E. Pinter2, A. Tedeschi3

Show more: Authors information and Publication history

Doi
10.23822/EurAnnACI.1764-1489.238

Summary
The autologous serum skin test (ASST) has been used in patients with chronic spontaneous urticaria (CSU) as a means to detect an auto reactivity state forthirty-five years now. Nonetheless, several aspects of this old diagnostic test are still insufficiently defined. Particularly, the nature of the factor(s) responsible for the appearance of the wheal-and-flare skin reaction is still poorly characterized. This article will review our current knowledge about the clinical significance of the ASST and the factors possibly associated with the occurrenceof the skin reaction following the intradermal administration of autologous serum that are known so far.

Key words
Chronic spontaneous urticaria; autologous serumskin test; autoreactivity; autoimmunity; histamine; histamine-releasing factors.

Cite this article as:
Asero R, Pinter E, Tedeschi A. 35 years of autologous serum skin test in chronic spontaneous urticaria: what we know and what we do not know. Eur Ann Allergy Clin Immunol. 2023;55(1):4-8. doi: 10.23822/EurAnnACI.1764-1489.238.

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