Allergology Clinic, Clinica San Carlo, Paderno Dugnano, Milan, Italy2
UOC Internal Medicine and Clinical Immunology, University of Rome La Sapienza, Policlinico Umberto I, Rome, Italy3
Department of Immunology Outpatient, UO General Medicine, Bolognini Hospital, ASST Bergamo Est, Seriate, Bergamo, ItalyHistory
Published: 14 December 2021
Accepted: 09 December 2021
Received: 10 November 2021
The autologous serum skin test (ASST) has been used in patients with chronic spontaneous urticaria (CSU) as a means to detect an auto reactivity state forthirty-five years now. Nonetheless, several aspects of this old diagnostic test are still insufficiently defined. Particularly, the nature of the factor(s) responsible for the appearance of the wheal-and-flare skin reaction is still poorly characterized. This article will review our current knowledge about the clinical significance of the ASST and the factors possibly associated with the occurrenceof the skin reaction following the intradermal administration of autologous serum that are known so far.
Chronic spontaneous urticaria; autologous serumskin test; autoreactivity; autoimmunity; histamine; histamine-releasing factors.