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Key elements in hypersensitivity reactions to chemotherapy: experience with rapid drug desensitization in gynaecological cancer in a Tertiary Hospital


I. Alen Coutinho iolandaalen@gmail.com1*, F. Costa Sousa2,3*, F. Cunha1, C. Frutuoso2, C. Ribeiro1, C. Loureiro1, F. Įguas2, A. Todo Bom1,4

Show more: Authors information and Publication history

Doi
10.23822/EurAnnACI.1764-1489.207

Summary
Rapid drug desensitization (RDD) is a procedure performed when no alternative drug is considered equally effective. The aim of our study is to describe the experience with RDD to cytostatics in patients being treated for gynaecological cancer in a Tertiary Hospital, over a period of 5 years. In this paper, we review 22 cases and 107 episodes of RDD; 86.3% of patients had advanced disease and the mortality rate at the time of data collection was 50.0%. RDD was performed on 81.8% patients for platinum, 13.6% for taxanes, and 4.5% for anthracyclines. The reintroduction of antineoplastic drugs in all patients with a previous history of immediate hypersensitivity reaction demonstrated the safety and efficacy of this procedure. There was serious complication (anaphylaxis) in only one case.

Key words
Adults; chemotherapy hypersensitivity reactions;gynaecological cancer; rapid desensitization; riskfactors.

Cite this article as:
Alen Coutinho I, Costa Sousa F, Cunha F, Frutuoso C, Ribeiro C, Loureiro C, Įguas F, Todo Bom A. Key elements in hypersensitivity reactions to chemotherapy: experience with rapid drug desensitization in gynaecological cancer in a Tertiary Hospital. Eur Ann Allergy Clin Immunol. 2022;54(6):265-276. doi: 10.23822/EurAnnACI.1764-1489.207.

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