Interleukin 13 gene polymorphism and susceptibility to asthma: a meta-regression and meta-analysis
M. Omraninava1, M. M. Eslami2, S. Aslani3, B. Razi2, D. Imani4, S. Feyzinia Sarafeyzinia@gmail.com5,6Show more: Authors information and Publication history1Department of Infectious Disease, Faculty of Medical Sciences, Sari Branch, Islamic Azad University, Sari, Iran
2Department of Hematology, School of Medicine, Tarbiat Modares University, Tehran, Iran
3Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
5Tuberclousis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
6Rahat Breath and Sleep Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
HistoryPublished: 16 November 2020
Accepted: 03 November 2020
Received: 29 September 2020
Doi10.23822/EurAnnACI.1764-1489.180Summary
Background. Previously, lots of studies researched the association of
interleukin (IL) 13 gene polymorphisms and the risk of asthma, yielding incongruent outcomes.
Objective. To resolve the inconsistency among the different studies, we performed the most up-to-date meta-analysis of IL13 gene
rs20541 and
rs1800925 polymorphisms and susceptibility to asthma.
Methods. After a systematic literature search up to September 2020, the pooled odds ratio (OR) and their corresponding 95% CI were extracted to determine the association level.
Results. Overall, 45 (containing 10572 cases and 11575 healthy controls) and 31 (containing 10139 cases and 13304 healthy controls) case-control studies for
rs20541 and
rs1800925 polymorphisms, respectively, were retrieved. Pooled analysis indicated statistically significant association of
rs20541 with asthma in the overall analysis. According to the subgroup analysis, significant association was detected between
rs20541 polymorphism in European population across dominant model, allelic model, and GA
vs GG model. A strongly significant association between
rs20541 polymorphism and asthma risk was identified in Asian population under all genetic models except heterozygote model. There was significant association between
rs20541 polymorphism and asthma risk in dominant, allelic and heterozygote models for Caucasians. The
rs1800925 single-nucleotide polymorphism (SNP) was associated with asthma risk in some genetic models for the overall, Asian, and European populations.
Conclusions. Both
rs20541 and
rs1800925 polymorphisms of IL13 gene confer a risk factor for asthma indifferent populations.
Key wordsAsthma; Meta-analysis; IL-13; polymorphism;genetic susceptibility.
Cite this article as:Omraninava M, Eslami MM, Aslani S, Razi B, Imani D, Feyzinia S. Interleukin 13 gene polymorphism and susceptibility to asthma: a meta-regression and meta-analysis. Eur Ann Allergy Clin Immunol. 2022;54(4):150-67. doi: 10.23822/EurAnnACI.1764-1489.180.
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