1Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Pediatrics, Yazd Branch, Islamic Azad University, Yazd, Iran
3Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4Faculty of Allied Medical Sciences, Zabol University of Medical Sciences, Zabol, Iran
5Department of Pharmacology, Faculty of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran
6Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
7Department of Biology, Science and Arts University, Yazd, Iran
8Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
HistoryPublished online: 04 June 2021
Accepted: 04 June 2021
Received: 12 July 2020
Studies evaluating the association of Interleukin 10 (IL-10) polymorphisms withrisk of pediatric asthma found inconsistent data. Here, we performed a meta-analysisto get a precise estimation of the associations. Relevant studies identified in thePubMed, Scopus, CNKI databases were used to perform a meta-analysis. A total of23 case-control studies including nine studies with 1298 cases and 1079 controls onIL-10-1082G>A, four studies with 622 cases and 603 controls on -819C>T andten studies with 1480 case and 1462 controls on -592C>A were selected. Overall,there was no significant association between IL-10 polymorphisms with pediatricasthma risk in global population. When stratified by ethnicity, there was a significantassociation of IL-10-1082G>A with pediatric asthma in Asians and Chinese. Thismeta-analysis result revealed that IL-10-1082G>A, -819C>T and -592C>A polymorphisms were not associated with pediatric asthma risk in the global population.
Pediatric athma; interleukin 10; cytokine; polymorphism; association.
Cite this article as:Dastgheib SA, Aarafi H, Bahrami R, Safa A, Khosravi-Bonjar A, Hashemzehi A, Noori-Shadkam M, Reza Mirjalili S, Salari S, Zare-Shehneh M, Neamatzadeh H. Association of IL-10-1082G>A, -819C>T and -592C>A polymorphisms with susceptibility to asthma in children: a Systematic Review and Meta-Analysis. Eur Ann Allergy Clin Immunol 2022;54(1):4-15. doi: 10.23822/EurAnnACI.1764-1489.219.
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