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Association of IL-10-1082G>A, -819C>T and -592C>A Polymorphisms with susceptibility to asthma in children: a Systematic Review and Meta-Analysis


S. A. Dastgheib1, H. Aarafi dr.hossein.arafi@gmail.com2, R. Bahrami3, A. Safa4, A. Khosravi-Bonjar4, A. Hashemzehi5, M. Noori-Shadkam6, S. Reza Mirjalili6, S. Salari7, H. Neamatzadeh6,8

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Doi
10.23822/EurAnnACI.1764-1489.219 

Summary

Studies evaluating the association of Interleukin 10 (IL-10) polymorphisms withrisk of pediatric asthma found inconsistent data. Here, we performed a meta-analysisto get a precise estimation of the associations. Relevant studies identified in thePubMed, Scopus, CNKI databases were used to perform a meta-analysis. A total of23 case-control studies including nine studies with 1298 cases and 1079 controls onIL-10-1082G>A, four studies with 622 cases and 603 controls on -819C>T andten studies with 1480 case and 1462 controls on -592C>A were selected. Overall,there was no significant association between IL-10 polymorphisms with pediatricasthma risk in global population. When stratified by ethnicity, there was a significantassociation of IL-10-1082G>A with pediatric asthma in Asians and Chinese. Thismeta-analysis result revealed that IL-10-1082G>A, -819C>T and -592C>A polymorphisms were not associated with pediatric asthma risk in the global population.
 
Key words
Pediatric athma; interleukin 10; cytokine; polymorphism; association.

Cite this article as:
Dastgheib SA, Aarafi H, Bahrami R, Safa A, Khosravi-Bonjar A, Hashemzehi A, Noori-Shadkam M, Reza Mirjalili S, Salari S, Zare-Shehneh M, Neamatzadeh H. Association of IL-10-1082G>A, -819C>T and -592C>A polymorphisms with susceptibility to asthma in children: a Systematic Review and Meta-Analysis. Eur Ann Allergy Clin Immunol 2022;54(1):4-15. doi: 10.23822/EurAnnACI.1764-1489.219.

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