Which skin prick test wheal size detects true allergy to Salsola kali?M. Al-Ahmad Alahmadm@hsc.edu.kw1,2, E. Jusufovic3, N. Arifhodzic1Show more: Authors information and Publication history
Al Rashed Allergy Centre, Kuwait city, Kuwait2
Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait city, Kuwait3
Faculty of Medicine, University of Tuzla, Tuzla, Bosnia and HerzegovinaHistory
Published: 09 September 2021
Accepted: 18 June 2020
Received: 2 January 2020
. Sensitization to Salsola kali (Sk) weed pollen allergen is the mostcommon cause of seasonal allergic rhinitis (SAR) in Middle East countries. Aim
. To identify Salsola kali skin prick test (SkSPT) wheal size cut-off, able to determine true allergy among adult patients with moderate to severe SAR, whoare in need of Salsola kali allergen specific immunotherapy (SkAIT). Methods
. In 151 adults with moderate to severe SAR, mean age 32.79 ± 10.79 years,of both gender (females: 43.05%), with a positive SkSPT, (i.e
., cut off wheallongest diameter of 3 mm) and one or more other local weed pollens, Salsolakali nasal provocation test (SkNPT) was carried out. Response was assessed both subjectively, with scores, and objectively, by measuring peak nasal inspiratory flow (PNIF). Safety profile of SkNPT was assessed using peak expiratory flow rate (PEF) measurements. Results
. SkNPT positive response was found in 125 patients (82.78%). Mean skin prick test (SPT) wheal size to Sk was bigger in the nasal provocatin test (NPT) positive group (9 mm) compared to the NPT negative patients (5 mm), p < 0.0001. ROC analysis showed that a SPT wheal size toSk at the threshold of > 7.5 mm enabled identification of SkNPT positivity with a sensitivity of 73.6% and specificity of 100.0% (area under the curve 0.9498, standard error 0.01808; 95% confidence interval (CI): 0.9144 to 0.9853; p < 0.0001). Conclusions
. SPT wheal size of 3 mm might overestimate the presenceof real allergy to Sk in a desert environment. A SPT wheal size > 7.5 mm forSk appears to distinguish individuals who develop disease from those who does not. Physicians should select the proper SPT wheal size value as an appropriate criterion according to the allergen than using a uniform cut off value in patients eligible for SkAIT.Key words
Salsola kali; skin prick test; nasal provocation test;allergy; sensitivity; specificity.
Cite this article as:
Al-Ahmad M, Jusufovic E, Arifhodzic N. Which skin prick test wheal size detects true allergy to Salsola kali? Eur Ann Allergy Clin Immunol 2021;53(5):228-233. doi: 10.23822/EurAnnACI.1764-1489.161.